Fort Wayne Metals Research and Development Engineers have co-authored an article for the Royal Society of Chemistry’s journal Chemical Communications. Titled “Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs”, the article describes that iron-containing metallic implants are shown to mediate hydrolysis of glycosidic linkages. This behavior can be leveraged using glucuronide prodrugs for broad-spectrum fluoroquinolone antibacterial agents, to perform localized synthesis of antimicrobials which affords a significant zone of inhibition of bacterial growth around the metallic material.
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